DePaul College Prep is a Vincentian Catholic high school, sponsored by the Congregation of the Mission, Western Province, also known as the Vincentians. The Vincentian fathers and brothers also sponsor DePaul University, the academic partner of DePaul College Prep.  From 1898-1968, the Vincentian fathers also sponsored DePaul Academy, a Vincentian high school located on the University’s Lincoln Park campus. Governance of DePaul College Prep is entrusted to a lay Board of Directors. The school is guided by the core values of Faith, Respect, Excellence, Service and Health and by our Vision to create an educated, just and compassionate world, one student at a time.

In 2012, a group of trustees and administrators of DePaul University was asked by the Archdiocese of Chicago and the priests and brothers of the Congregation of the Resurrection to assist Gordon Tech High School.  As the academic partnership with DePaul University progressed successfully, the school officially became DePaul College Prep in 2014. 

In July 2019, in response to a rapidly growing enrollment, DePaul College Prep’s Board of Directors acquired a new 17-acre campus and modern school buildings at 3300 N. Campbell, Chicago, Illinois.  DePaul College Prep moved its operations to the new campus in August 2020. The religious sponsorship of the school transferred from the Resurrectionists to the Vincentians in September 2019.

In August 2020, DePaul College Prep proudly began the 2020-2021 school year on the school's new campus. 

Each day, the school community of DePaul Prep strives to respond to the central question posed by St. Vincent de Paul more than 300 years ago:  What must be done?  DePaul Prep is proud of how its students and faculty follow the examples of St. Vincent and St. Louise de Marillac to serve those who live on the margins of society.  DePaul Prep’s students provide thousands of hours of service annually at a variety of not for profit organizations in the City of Chicago, in rural areas of our country and in central America.

DePaul Prep offers college prep, AP, Honors and International Baccalaureate classes on campus and dual enrollment classes at DePaul University, and is proud to educate young adults of Chicago to meet the challenges of the 21st century.