DePaul College Prep is a Vincentian Catholic High School sponsored by the Congregation of the Mission, Western Province, also known as the Vincentians. The Vincentian fathers and brothers also sponsor DePaul University, the academic partner of DePaul College Prep. From 1898-1968, the Vincentian fathers also sponsored DePaul Academy, a Vincentian high school located on the University's Lincoln Park campus. Governance of DePaul College Prep is entrusted to a lay Board of Directors. The school is guided by the core values of Faith, Respect, Excellence, Service, and Health, and by our Vision to create an educated, just, and compassionate world, one student at a time. 

In 2012, a group of trustees and administrators of DePaul University was asked by the Archdiocese of Chicago and the priests and brothers of the Congregation of the Resurrection to assist Gordon Tech High School. As the academic partnership with DePaul University progressed successfully, the school officially became DePaul College Prep in 2014. 

In July 2019, in response to rapidly growing enrollment, DePaul College Prep's Board of Directors acquired a new 17-acre campus and modern school buildings at 3300 N. Campbell, Chicago, Illinois. DePaul College Prep moved its operations to the new campus in August 2020. The religious sponsorship of the school transferred from the Resurrectionists to the Vincentians in September 2019. 

DePaul College Prep proudly began the 2020-2021 school year on the school's new campus. The 17-acre campus includes the 178,000 square foot Mary A. Dempsey Academic Center comprised of 62 modern classrooms, two student dining halls, four maker spaces, ten science labs, Black Box Theater, strength training and weight room, library, chapel, and two student gathering places. The campus also includes an organic teaching garden, greenhouse, grass practice field, and 1,800 seat turf field stadium. 

Students choose from a wide range of course offerings, including College Prep, Honors, Advanced Placement (AP), and International Baccalaureate (IB) classes. Thanks to our academic partnership with DePaul University, DePaul Prep students can enroll in dual enrollment classes at DePaul University. In response to the central Vincentian question, 'What must be done?', DePaul Prep's students provide thousands of hours of service annually at a variety of not for profit organizations in Chicago and elsewhere.